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Interestingly, the low uptake of AuNPs-PEI 2KD could be enhanced by modification with a targeting ligand (such as anisic acid (AA) or folic acid (FA)) [17, 23]

Moreover, cigarette smoke induces chronic inflammation, which results in immune cell exhaustion and generally attenuates the function of many immune responses (108)

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The NLRP3 inflammasome activates IL1 and IL18, and consistent with the increased expression of NLRP3 and IL1 in the RPE/choroids of eyes of VEGFA hyper mice, we found that the NLRP3 inflammasome promotes VEGFAinduced CNV lesion formation through the proangiogenic factor IL1, as genetic inactivation of Nlrp3 or Il1r1 potently reduced the numbers of CNV lesions that formed in VEGFA hyper mice (Fig 8AE and Appendix Fig S5A and B)